Radioprotective Effects of Allium jesdianum Extract on Reduction of Pancrease Damages Following γ-Radiation through Down-regulation of Apoptotic Genes, Antioxidants Regulation, and Suppression of Inflammatory Markers

Background: Allium jesdianum (AJ), as a plant in onion category, has antioxidant features. Moreover, γ-ray potentially generates oxidative stress living organisms. Objectives: In this study, the probable therapeutic effects of AJ on destruction pancreas tissue following were evaluated. Methods: Sixty-four mature NMRI mice (8 animals each group) assigned to eight groups follows: (1) Control; (2) (dose rate 1 Gy/min); (3-5) extract (500, 1,000, and 2,000 mg/kg); (6-8) + γ-ray. was prepared, all administrations applied orally for 70 consecutive days. Antioxidant parameters (nitrite oxide, peroxidation, ferric reducing ability plasma (FRAP)), expression apoptotic genes (p53 Bax, by quantitative real-time PCR), blood concentrations glucose insulin determined biochemically genetically. Inflammatory cytokines evaluated ELISA technique. The number diameter Langerhan islets also studied histologically. Results: increased levels significantly (except FRAP, insulin, morphometric parameters, which reduced) group compared control (P < 0.05). groups, factors reduced increased) Conclusions: Administration can decrease damage radiosensitization pancreatic cells induced